There are just five years to go to reach the Sustainable Development Goals, the World Health Organization (WHO) Neglected Tropical Diseases (NTDs) Roadmap 2030, the 2016-2030 Global Technical Strategy for Malaria, and the Immunization Agenda 2030. These goals have become even more challenging for many low- and middle-income countries in the context of recent seismic shifts in the funding landscape for global health. At the same time, there is new momentum, including through the Lusaka Agenda and other ongoing processes, behind decade-old efforts to increase alignment between disease-specific global health initiatives and programs. Such initiatives risk competition for engagement from local health workers and communities and pose structural barriers to integration – which, under the right circumstances, seems to offer potential to achieve more sustainable impact with limited resources. In this viewpoint from the Integration Working Group, we use examples from integration of NTDs to argue that the time for integration is now. We call for governments to push for integrated planning – including across sectors–and for the international community to incentivise integration and support efforts to consolidate knowledge and best practice.